InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGF1

Summary

InnateDB Protein

IDBP-53613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF1

Protein Name

insulin-like growth factor 1 (somatomedin C)

Synonyms

IGF-I; IGF1A; IGFI;

Species

Homo sapiens

Ensembl Protein

ENSP00000302665

InnateDB Gene

IDBG-53609 (IGF1)

Protein Structure

UniProt Annotation

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. {ECO:0000269PubMed:21076856, ECO:0000269PubMed:24132240}.

Subcellular Localization

Secreted.

Disease Associations

Insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]: Autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. {ECO:0000269PubMed:8857020}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005178	integrin binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001775	cell activation
GO:0001932	regulation of protein phosphorylation
GO:0001974	blood vessel remodeling
GO:0002576	platelet degranulation
GO:0006260	DNA replication
GO:0006928	cellular component movement
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0007399	nervous system development
GO:0007517	muscle organ development
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009441	glycolate metabolic process
GO:0010001	glial cell differentiation
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896	muscle hypertrophy
GO:0014904	myotube cell development
GO:0014911	positive regulation of smooth muscle cell migration
GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
GO:0030104	water homeostasis
GO:0030166	proteoglycan biosynthetic process
GO:0030168	platelet activation
GO:0030324	lung development
GO:0030879	mammary gland development
GO:0031017	exocrine pancreas development
GO:0032878	regulation of establishment or maintenance of cell polarity
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0035264	multicellular organism growth
GO:0035630	bone mineralization involved in bone maturation
GO:0040014	regulation of multicellular organism growth
GO:0042104	positive regulation of activated T cell proliferation
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066	negative regulation of apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0043410	positive regulation of MAPK cascade
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045445	myoblast differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045740	positive regulation of DNA replication
GO:0045821	positive regulation of glycolytic process
GO:0045840	positive regulation of mitosis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046326	positive regulation of glucose import
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048146	positive regulation of fibroblast proliferation
GO:0048286	lung alveolus development
GO:0048468	cell development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048839	inner ear development
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051246	regulation of protein metabolic process
GO:0051450	myoblast proliferation
GO:0051897	positive regulation of protein kinase B signaling
GO:0060426	lung vasculature development
GO:0060463	lung lobe morphogenesis
GO:0060509	Type I pneumocyte differentiation
GO:0060510	Type II pneumocyte differentiation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736	prostate gland growth
GO:0060740	prostate gland epithelium morphogenesis
GO:0060741	prostate gland stromal morphogenesis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070886	positive regulation of calcineurin-NFAT signaling cascade
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000288	positive regulation of myoblast proliferation
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016942	insulin-like growth factor binding protein complex
GO:0031093	platelet alpha granule lumen