InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OTX1

Summary

InnateDB Protein

IDBP-53616.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OTX1

Protein Name

orthodenticle homeobox 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000282549

InnateDB Gene

IDBG-53614 (OTX1)

Protein Structure

UniProt Annotation

Function

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in brain. Detected in the anterior part of the neural fetal retina (at protein level). {ECO:0000269PubMed:19414065}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0009952	anterior/posterior pattern specification
GO:0022037	metencephalon development
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0042472	inner ear morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048852	diencephalon morphogenesis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR003025 Transcription factor Otx
IPR003026 Transcription factor Otx1
IPR009057 Homeodomain-like
IPR013851 Transcription factor Otx, C-terminal

PFAM

PF00046
PF03529

PRINTS

PR01255
PR01256

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt