InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC61A2

Summary

InnateDB Protein

IDBP-53625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC61A2

Protein Name

Sec61 alpha 2 subunit (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000298428

InnateDB Gene

IDBG-53617 (SEC61A2)

Protein Structure

UniProt Annotation

Function

Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0043022	ribosome binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0008150	biological_process
GO:0015031	protein transport
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I