InnateDB Protein
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IDBP-536551.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Akap1
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Protein Name
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A kinase (PRKA) anchor protein 1
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Synonyms
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Akap; AKAP121; AKAP84; C76494; C81186; DAKAP1; S-AKAP84;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000122295
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InnateDB Gene
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IDBG-208001 (Akap1)
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Protein Structure
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Function |
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif.
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Subcellular Localization |
Isoform 2: Endoplasmic reticulum.Isoform 4: Endoplasmic reticulum.Isoform 1: Mitochondrion outer membrane.Isoform 3: Mitochondrion outer membrane.Isoform 5: Mitochondrion outer membrane.Isoform 6: Mitochondrion outer membrane.
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Disease Associations |
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Tissue Specificity |
Highest expression in testis, heart, liver, skeletal muscle, intestine and kidney, followed by brain and lung. No expression in spleen. Isoform 1/D-AKAP1A is expressed predominantly in testis whereas isoform 4/D-AKAP1D is expressed primarily in liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104729
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InterPro |
IPR018459
RII binding domain
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PFAM |
PF10522
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O08715
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PhosphoSite |
PhosphoSite-O08715
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11640
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UniGene |
Mm.465395
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RefSeq |
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MGI ID |
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MGI Symbol |
Akap1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AL596180
U84389
U95145
U95146
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GenPept |
AAB53740
AAB53741
AAC27100
CAI24699
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