Version 5.4
Mus musculus Protein: Dlgap1
Summary
InnateDB Protein IDBP-536682.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlgap1
Protein Name discs, large (Drosophila) homolog-associated protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000116716
InnateDB Gene IDBG-196333 (Dlgap1)
Protein Structure
UniProt Annotation
Function Part of the postsynaptic scaffold in neuronal cells.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000269PubMed:24153177}.
Disease Associations
Tissue Specificity Highest levels in the neocortex, part of the hippocampus, the granule cell layer of the cerebellum, the glomerular layer of the olfactory bulb, the inner plexiform layer of the retina, the ventral and dorsal horn of the spinal chord, the neuromuscular junction and the submandibular ganglion. {ECO:0000269PubMed:15024750}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
Cellular Component
GO:0030054 cell junction
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0097481 neuronal postsynaptic density
Protein Structure and Domains
PDB ID MGI:1346065
InterPro IPR005026 Guanylate-kinase-associated protein
PFAM PF03359
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D415
PhosphoSite PhosphoSite-Q9D415
TrEMBL Q3UHD8
UniProt Splice Variant
Entrez Gene 224997
UniGene Mm.396827
RefSeq XP_006524238
MGI ID
MGI Symbol Dlgap1
OMIM
CCDS
HPRD
IMGT
EMBL AK031410 AK033901 AK034182 AK147448 AK220515 AY243846 BC062120 BC094369
GenPept AAH62120 AAH94369 AAP70755 BAC27391 BAC28508 BAC28619 BAD90519 BAE27919

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca