Version 5.4
| Homo sapiens Protein: TSPEAR | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-5368.5 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TSPEAR | ||||||||
| Protein Name | thrombospondin-type laminin G domain and EAR repeats | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000321987 | ||||||||
| InnateDB Gene | IDBG-5364 (TSPEAR) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May play a role in development or function of the auditory system. | ||||||||
| Subcellular Localization | Secreted {ECO:0000250}. Cell surface {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}. Note=Secreted protein which may bind to the cell surface via a membrane receptor. {ECO:0000250}. | ||||||||
| Disease Associations | Deafness, autosomal recessive, 98 (DFNB98) [MIM:614861]: A form of non-syndromic sensorineural hearing loss with prelingual onset. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:22678063}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001791
Laminin G domain IPR005492 Leucine-rich glioma-inactivated , EPTP repeat IPR008985 Concanavalin A-like lectin/glucanases superfamily IPR009039 EAR |
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| PFAM |
PF00054
PF02210 PF03736 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00210
SM00282 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8WU66 | ||||||||
| PhosphoSite | PhosphoSite-Q8WU66 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 54084 | ||||||||
| UniGene | Hs.660703 | ||||||||
| RefSeq | NP_659428 | ||||||||
| HUGO | HGNC:1268 | ||||||||
| OMIM | 612920 | ||||||||
| CCDS | CCDS13712 | ||||||||
| HPRD | 09845 | ||||||||
| IMGT | |||||||||
| EMBL | AJ487962 BC021197 | ||||||||
| GenPept | AAH21197 CAD32309 | ||||||||