Version 5.4
Mus musculus Protein: Fyn
Summary
InnateDB Protein IDBP-536817.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fyn
Protein Name Fyn proto-oncogene
Synonyms AI448320; AW552119;
Species Mus musculus
Ensembl Protein ENSMUSP00000117837
InnateDB Gene IDBG-144629 (Fyn)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 270 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 84 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 270 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0046875 ephrin receptor binding
GO:0051428 peptide hormone receptor binding
GO:0070851 growth factor receptor binding
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0007166 cell surface receptor signaling pathway
GO:0008360 regulation of cell shape
GO:0010976 positive regulation of neuron projection development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030900 forebrain development
GO:0042177 negative regulation of protein catabolic process
GO:0042493 response to drug
GO:0042552 myelination
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045471 response to ethanol
GO:0046777 protein autophosphorylation
GO:0048813 dendrite morphogenesis
GO:0050798 activated T cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0071363 cellular response to growth factor stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:1900182 positive regulation of protein localization to nucleus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
Protein Structure and Domains
PDB ID MGI:95602
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YVZ0
UniProt Splice Variant
Entrez Gene 14360
UniGene Mm.4848
RefSeq
MGI ID
MGI Symbol Fyn
OMIM
CCDS
HPRD
IMGT
EMBL AC153422 AC153537
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca