InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc11a2

Summary

InnateDB Protein

IDBP-536835.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc11a2

Protein Name

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

Synonyms

DCT1; DMT1; mk; Nramp2; van;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114702

InnateDB Gene

IDBG-184534 (Slc11a2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005381	iron ion transmembrane transporter activity
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0015087	cobalt ion transmembrane transporter activity
GO:0015093	ferrous iron transmembrane transporter activity

Biological Process

GO:0006778	porphyrin-containing compound metabolic process
GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006810	transport
GO:0006824	cobalt ion transport
GO:0006826	iron ion transport
GO:0007611	learning or memory
GO:0015684	ferrous iron transport
GO:0015992	proton transport
GO:0048813	dendrite morphogenesis
GO:0048821	erythrocyte development
GO:0060586	multicellular organismal iron ion homeostasis
GO:0070627	ferrous iron import
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0009986	cell surface
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

MGI:1345279

InterPro

IPR001046 Natural resistance-associated macrophage like

PFAM

PF01566

PRINTS

PR00447

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F6ZM31

UniProt Splice Variant

Entrez Gene

18174

UniGene

Mm.415770

RefSeq

MGI ID

MGI Symbol

Slc11a2

OMIM

CCDS

HPRD

IMGT

EMBL

AC139571

GenPept