InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hgd

Summary

InnateDB Protein

IDBP-537170.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hgd

Protein Name

homogentisate 1, 2-dioxygenase

Synonyms

aku; Hgo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125492

InnateDB Gene

IDBG-159602 (Hgd)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Note=Defects in Hgd are the cause of alkaptonuria (aku). Aku is an autosomal recessive error of metabolism which is characterized by an increase in the level of homogentisic acid.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004411	homogentisate 1,2-dioxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006559	L-phenylalanine catabolic process
GO:0006570	tyrosine metabolic process
GO:0006572	tyrosine catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96078

InterPro

IPR005708 Homogentisate 1,2-dioxygenase
IPR011051 RmlC-like cupin domain

PFAM

PF04209

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O09173

PhosphoSite

PhosphoSite-O09173

TrEMBL

UniProt Splice Variant

Entrez Gene

15233

UniGene

RefSeq

NP_038575

MGI ID

MGI Symbol

Hgd

OMIM

CCDS

CCDS49849

HPRD

IMGT

EMBL

BC055029 CH466521 U58988

GenPept

AAC53224 AAH55029 EDK97961