Version 5.4
Mus musculus Protein: Trdmt1
Summary
InnateDB Protein IDBP-537237.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trdmt1
Protein Name tRNA aspartic acid methyltransferase 1
Synonyms Dnmt2; Rnmt2;
Species Mus musculus
Ensembl Protein ENSMUSP00000114572
InnateDB Gene IDBG-137772 (Trdmt1)
Protein Structure
UniProt Annotation
Function Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in thymus, testis, and at much lower levels in spleen, lung, brain, heart, kidney, liver, skeletal muscle and embryonic stem cells. {ECO:0000269PubMed:9592134}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
Biological Process
GO:0001975 response to amphetamine
GO:0006306 DNA methylation
GO:0030488 tRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1274787
InterPro IPR001525 C-5 cytosine methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF00145
PRINTS PR00105
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O55055
PhosphoSite PhosphoSite-O55055
TrEMBL Q5I0V6
UniProt Splice Variant
Entrez Gene 13434
UniGene Mm.6979
RefSeq NP_034197
MGI ID
MGI Symbol Trdmt1
OMIM
CCDS CCDS15695
HPRD
IMGT
EMBL AF012129 AF045889 BC087892 CH466542
GenPept AAC40130 AAC53529 AAH87892 EDL08052

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca