InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map2k2

Summary

InnateDB Protein

IDBP-537249.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map2k2

Protein Name

mitogen-activated protein kinase kinase 2

Synonyms

AA589381; MEK2; MK2; Prkmk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121111

InnateDB Gene

IDBG-176971 (Map2k2)

Protein Structure

UniProt Annotation

Function

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. {ECO:0000269PubMed:19219045}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in adult intestine, kidney, liver, lung, pancreas, spleen, thymus, and at high levels in the neonatal brain. Lower expression is found in adult brain and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030165	PDZ domain binding
GO:0032947	protein complex scaffold
GO:0043539	protein serine/threonine kinase activator activity
GO:0097110	scaffold protein binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032872	regulation of stress-activated MAPK cascade
GO:0036289	peptidyl-serine autophosphorylation
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090170	regulation of Golgi inheritance
GO:2000147	positive regulation of cell motility
GO:2000641	regulation of early endosome to late endosome transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0009898	cytoplasmic side of plasma membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1346867

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt