Version 5.4
Mus musculus Protein: Prkcz
Summary
InnateDB Protein IDBP-537438.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkcz
Protein Name protein kinase C, zeta
Synonyms AI098070; aPKCzeta; C80388; nPKC-zeta; Pkcz; R74924; zetaPKC;
Species Mus musculus
Ensembl Protein ENSMUSP00000116042
InnateDB Gene IDBG-207513 (Prkcz)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 37 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 96 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004697 protein kinase C activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015459 potassium channel regulator activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0043274 phospholipase binding
GO:0046872 metal ion binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001954 positive regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0007616 long-term memory
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0030010 establishment of cell polarity
GO:0031333 negative regulation of protein complex assembly
GO:0031532 actin cytoskeleton reorganization
GO:0031584 activation of phospholipase D activity
GO:0032148 activation of protein kinase B activity
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0046326 positive regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0047496 vesicle transport along microtubule
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051222 positive regulation of protein transport
GO:0051291 protein heterooligomerization
GO:0051346 negative regulation of hydrolase activity
GO:0060081 membrane hyperpolarization
GO:0060291 long-term synaptic potentiation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0072659 protein localization to plasma membrane
GO:1990138 neuron projection extension
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0016324 apical plasma membrane
GO:0016363 nuclear matrix
GO:0031252 cell leading edge
GO:0043203 axon hillock
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0045179 apical cortex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:97602
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020454 Diacylglycerol/phorbol-ester binding
PFAM PF00130
PRINTS PR00008
PIRSF
SMART SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2AD74
UniProt Splice Variant
Entrez Gene 18762
UniGene Mm.400328
RefSeq
MGI ID
MGI Symbol Prkcz
OMIM
CCDS
HPRD
IMGT
EMBL AL670227 AL670413
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca