InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Oprk1

Summary

InnateDB Protein

IDBP-537514.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oprk1

Protein Name

opioid receptor, kappa 1

Synonyms

K-OR-1; KOR; KOR-1; MSL-1; Oprk2; R21;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124030

InnateDB Gene

IDBG-131811 (Oprk1)

Protein Structure

UniProt Annotation

Function

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269PubMed:8393575, ECO:0000269PubMed:9463367}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:8393575, ECO:0000269PubMed:9463367}; Multi-pass membrane protein {ECO:0000269PubMed:8393575, ECO:0000269PubMed:9463367}.

Disease Associations

Tissue Specificity

Detected in brain (at protein level). Brain (neocortex, hippocampus, amygdala, medial habenula, hypothalamus, locus ceruleus, and parabrachial nucleus). {ECO:0000269PubMed:8393575, ECO:0000269PubMed:9463367}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004985	opioid receptor activity
GO:0038048	dynorphin receptor activity

Biological Process

GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007626	locomotory behavior
GO:0019233	sensory perception of pain
GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway
GO:0046877	regulation of saliva secretion
GO:0051607	defense response to virus

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:97439

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000452 Kappa opioid receptor
IPR000586 Somatostatin receptor family
IPR000611 Neuropeptide Y receptor family
IPR001418 Opioid receptor
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR00532
PR00246
PR01012
PR00384
PR01855

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33534