InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alpl

Summary

InnateDB Protein

IDBP-537522.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alpl

Protein Name

alkaline phosphatase, liver/bone/kidney

Synonyms

Akp-2; Akp2; APTNAP; TNAP; TNSALP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125041

InnateDB Gene

IDBG-199139 (Alpl)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	3 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004035	alkaline phosphatase activity
GO:0005515	protein binding
GO:0016462	pyrophosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0001958	endochondral ossification
GO:0003006	developmental process involved in reproduction
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0032496	response to lipopolysaccharide
GO:0033280	response to vitamin D
GO:0046677	response to antibiotic
GO:0051384	response to glucocorticoid
GO:0071407	cellular response to organic cyclic compound
GO:0071529	cementum mineralization

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0031012	extracellular matrix
GO:0065010	extracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:87983

InterPro

IPR001952 Alkaline phosphatase
IPR017850 Alkaline-phosphatase-like, core domain

PFAM

PF00245

PRINTS

PR00113

PIRSF

SMART

SM00098

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9Q7P8

UniProt Splice Variant

Entrez Gene

11647

UniGene

Mm.456447

RefSeq

MGI ID

MGI Symbol

Alpl

OMIM

CCDS

HPRD

IMGT

EMBL

AL805954 AL807764

GenPept