Version 5.4
Mus musculus Protein: Shc1
Summary
InnateDB Protein IDBP-537556.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shc1
Protein Name src homology 2 domain-containing transforming protein C1
Synonyms p66; p66shc; Shc; ShcA;
Species Mus musculus
Ensembl Protein ENSMUSP00000123635
InnateDB Gene IDBG-164495 (Shc1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 201 interaction(s) predicted by orthology.
Experimentally validated
Total 77 [view]
Protein-Protein 77 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 201 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0007507 heart development
GO:0016337 single organismal cell-cell adhesion
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID MGI:98296
InterPro IPR006019 Phosphotyrosine interaction domain, Shc-like
IPR006020 PTB/PI domain
PFAM PF00640
PF14719
PRINTS PR00629
PIRSF
SMART SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YXZ9
UniProt Splice Variant
Entrez Gene 20416
UniGene Mm.86595
RefSeq
MGI ID
MGI Symbol Shc1
OMIM
CCDS
HPRD
IMGT
EMBL AC171273
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca