InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdca2

Summary

InnateDB Protein

IDBP-537636.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdca2

Protein Name

cell division cycle associated 2

Synonyms

2610311M19Rik; AI586158;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117847

InnateDB Gene

IDBG-176041 (Cdca2)

Protein Structure

UniProt Annotation

Function

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.