Version 5.4
Mus musculus Protein: Dpm1
Summary
InnateDB Protein IDBP-537664.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dpm1
Protein Name dolichol-phosphate (beta-D) mannosyltransferase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000118776
InnateDB Gene IDBG-262910 (Dpm1)
Protein Structure
UniProt Annotation
Function Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0035268 protein mannosylation
GO:0035269 protein O-linked mannosylation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:1330239
InterPro IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF00535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O70152
PhosphoSite PhosphoSite-O70152
TrEMBL
UniProt Splice Variant
Entrez Gene 13480
UniGene Mm.422657
RefSeq NP_034202
MGI ID
MGI Symbol Dpm1
OMIM
CCDS CCDS17109
HPRD
IMGT
EMBL AB004789 AK004834 AK005268 AK008548 BC061151
GenPept AAH61151 BAA25759 BAB23602 BAB23920 BAB25735

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca