Version 5.4
Mus musculus Protein: Myd88
Summary
InnateDB Protein IDBP-537666.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myd88
Protein Name myeloid differentiation primary response gene 88
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000115746
InnateDB Gene IDBG-204565 (Myd88)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Experimentally validated
Total 99 [view]
Protein-Protein 88 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 1 [view]
DNA-RNA 1 [view]
Predicted by orthology
Total 86 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002238 response to molecule of fungal origin
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009615 response to virus
GO:0016064 immunoglobulin mediated immune response
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042127 regulation of cell proliferation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044130 negative regulation of growth of symbiont in host
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045351 type I interferon biosynthetic process
GO:0046330 positive regulation of JNK cascade
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0090557 establishment of endothelial intestinal barrier
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:108005
InterPro IPR000488 Death domain
IPR011029 Death-like domain
PFAM PF00531
PRINTS
PIRSF
SMART SM00005
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F6SPW1
UniProt Splice Variant
Entrez Gene 17874
UniGene Mm.471560
RefSeq
MGI ID
MGI Symbol Myd88
OMIM
CCDS
HPRD
IMGT
EMBL AC128702
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca