Version 5.4
Mus musculus Protein: Myh6
Summary
InnateDB Protein IDBP-537688.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myh6
Protein Name myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms A830009F23Rik; AA517445; alpha-MHC; Myhc-a; Myhca;
Species Mus musculus
Ensembl Protein ENSMUSP00000116370
InnateDB Gene IDBG-162609 (Myh6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008307 structural constituent of muscle
GO:0019901 protein kinase binding
GO:0030898 actin-dependent ATPase activity
GO:0051015 actin filament binding
Biological Process
GO:0001701 in utero embryonic development
GO:0002026 regulation of the force of heart contraction
GO:0002027 regulation of heart rate
GO:0006200 ATP catabolic process
GO:0006941 striated muscle contraction
GO:0007512 adult heart development
GO:0007522 visceral muscle development
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0030048 actin filament-based movement
GO:0030049 muscle filament sliding
GO:0030239 myofibril assembly
GO:0030509 BMP signaling pathway
GO:0043462 regulation of ATPase activity
GO:0045214 sarcomere organization
GO:0048739 cardiac muscle fiber development
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060420 regulation of heart growth
Cellular Component
GO:0001725 stress fiber
GO:0005730 nucleolus
GO:0005925 focal adhesion
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0030018 Z disc
Protein Structure and Domains
PDB ID MGI:97255
InterPro IPR004009 Myosin, N-terminal, SH3-like
IPR008989 Myosin S1 fragment, N-terminal
PFAM PF02736
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q1WNP4
UniProt Splice Variant
Entrez Gene 17888
UniGene Mm.290003
RefSeq
MGI ID
MGI Symbol Myh6
OMIM
CCDS
HPRD
IMGT
EMBL CT025533 DQ023232 DQ023233 DQ023234 DQ023235 DQ023236 DQ023237
GenPept AAY86373 AAY86374 AAY86375 AAY86376 AAY86377 AAY86378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca