InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vwc2l

Summary

InnateDB Protein

IDBP-537734.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vwc2l

Protein Name

von Willebrand factor C domain-containing protein 2-like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123819

InnateDB Gene

IDBG-164407 (Vwc2l)

Protein Structure

UniProt Annotation

Function

May play a role in neurogenesis. May promote matrix mineralization (PubMed:22209847), but has been shown to weakly, but significantly inhibit BMP2 and BMP6 activity in a preosteoblastic cell line (PubMed:19852960). {ECO:0000269PubMed:19852960, ECO:0000269PubMed:22209847}.

Subcellular Localization

Secreted. Cell junction, synapse {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in the brain (at protein level). Also detected in bones, including femur and calvaria, heart, lung and kidney. Isoform 5 is predominant in lung and heart, compared to isoforms 1 and 3. Isoform 4 is expressed in femur and calvaria at higher levels than isoforms 1 and 5. Isoforms 1 and 4 are expressed at higher levels than isoform 5 in kidney and brain. {ECO:0000269PubMed:19852960, ECO:0000269PubMed:22209847, ECO:0000269PubMed:22632720}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0030514	negative regulation of BMP signaling pathway
GO:0045666	positive regulation of neuron differentiation

Cellular Component

GO:0005615	extracellular space
GO:0030054	cell junction
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045202	synapse