InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc9a10

Summary

InnateDB Protein

IDBP-537812.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc9a10

Protein Name

solute carrier family 9, member 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124969

InnateDB Gene

IDBG-162975 (Slc9a10)

Protein Structure

UniProt Annotation

Function

Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC). {ECO:0000269PubMed:14634667, ECO:0000269PubMed:17517652}.

Subcellular Localization

Cell projection, cilium, flagellum membrane {ECO:0000269PubMed:14634667}; Multi-pass membrane protein {ECO:0000269PubMed:14634667}.

Disease Associations

Tissue Specificity

Testis-specific. Specifically present in the principal piece of sperm tail (at protein level). {ECO:0000269PubMed:14634667}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015299	solute:proton antiporter activity

Biological Process

GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0030317	sperm motility
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport