Version 5.4
Mus musculus Protein: Wtap
Summary
InnateDB Protein IDBP-537817.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wtap
Protein Name Wilms' tumour 1-associating protein
Synonyms 2810408K05Rik; 9430038B09Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000124138
InnateDB Gene IDBG-137755 (Wtap)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0007049 cell cycle
GO:0007275 multicellular organismal development
GO:0008380 RNA splicing
GO:0080009 mRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0036396 MIS complex
Protein Structure and Domains
PDB ID MGI:1926395
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ER69
PhosphoSite PhosphoSite-Q9ER69
TrEMBL Q571E0
UniProt Splice Variant
Entrez Gene 60532
UniGene Mm.490351
RefSeq NP_780603
MGI ID
MGI Symbol Wtap
OMIM
CCDS CCDS49949
HPRD
IMGT
EMBL AJ276707 AK076111 AK156334 AK220249 AL589878 BC046416 BC093504
GenPept AAH46416 AAH93504 BAC36191 BAD90174 BAE33680 CAC16790

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca