InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nbn

Summary

InnateDB Protein

IDBP-537893.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nbn

Protein Name

nibrin

Synonyms

Nbs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120829

InnateDB Gene

IDBG-130577 (Nbn)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000723	telomere maintenance
GO:0006302	double-strand break repair
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0007126	meiotic nuclear division
GO:0008283	cell proliferation
GO:0031954	positive regulation of protein autophosphorylation
GO:0032508	DNA duplex unwinding
GO:0033674	positive regulation of kinase activity
GO:0050885	neuromuscular process controlling balance
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005730	nucleolus
GO:0016605	PML body
GO:0030870	Mre11 complex
GO:0035861	site of double-strand break
GO:0042405	nuclear inclusion body

Protein Structure and Domains

PDB ID

MGI:1351625

InterPro

IPR000253 Forkhead-associated (FHA) domain
IPR001357 BRCT domain
IPR008984 SMAD/FHA domain
IPR016592 Nibrin

PFAM

PF00498
PF00533
PF12738

PRINTS

PIRSF

PIRSF011869

SMART

SM00240
SM00292

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2AMG5

UniProt Splice Variant

Entrez Gene

27354

UniGene

RefSeq

MGI ID

MGI Symbol

Nbn

OMIM

CCDS

HPRD

IMGT

EMBL

AL807737

GenPept