InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fzd3

Summary

InnateDB Protein

IDBP-537897.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fzd3

Protein Name

frizzled homolog 3 (Drosophila)

Synonyms

AU020229; D930050A07Rik; Fz3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115325

InnateDB Gene

IDBG-174092 (Fzd3)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G- protein-dependent mechanism.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the CNS. In skin, it is restricted to the epidermis and to the developing hair follicle. {ECO:0000269PubMed:11407985, ECO:0000269PubMed:8626800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001736	establishment of planar polarity
GO:0001764	neuron migration
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0001944	vasculature development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008406	gonad development
GO:0021754	facial nucleus development
GO:0030901	midbrain development
GO:0033278	cell proliferation in midbrain
GO:0036342	post-anal tail morphogenesis
GO:0042472	inner ear morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0071679	commissural neuron axon guidance

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0032589	neuron projection membrane
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0048786	presynaptic active zone