InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stxbp4

Summary

InnateDB Protein

IDBP-537899.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stxbp4

Protein Name

syntaxin binding protein 4

Synonyms

6030470M02Rik; Synip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116191

InnateDB Gene

IDBG-208360 (Stxbp4)

Protein Structure

UniProt Annotation

Function

Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. {ECO:0000269PubMed:10394363, ECO:0000269PubMed:12855681}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10394363}.

Disease Associations

Tissue Specificity

Detected in skeletal muscle, heart, testis, adipocytes and pancreatic islet cells. {ECO:0000269PubMed:10394363, ECO:0000269PubMed:12855681}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006605	protein targeting
GO:0006974	cellular response to DNA damage stimulus
GO:0008286	insulin receptor signaling pathway
GO:0010838	positive regulation of keratinocyte proliferation
GO:0015758	glucose transport
GO:0050821	protein stabilization
GO:1902808	positive regulation of cell cycle G1/S phase transition