InnateDB Protein
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IDBP-537926.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rgs2
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Protein Name
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regulator of G-protein signaling 2
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Synonyms
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GOS8;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000115558
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InnateDB Gene
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IDBG-197102 (Rgs2)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
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Subcellular Localization |
Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in a wide variety of tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
54 [view]
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Molecular Function |
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Biological Process |
GO:0006417
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regulation of translation
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GO:0007049
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cell cycle
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0007283
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spermatogenesis
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GO:0010519
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negative regulation of phospholipase activity
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GO:0010614
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negative regulation of cardiac muscle hypertrophy
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GO:0031116
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positive regulation of microtubule polymerization
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043407
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negative regulation of MAP kinase activity
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GO:0043547
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positive regulation of GTPase activity
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GO:0043951
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negative regulation of cAMP-mediated signaling
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GO:0045087
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innate immune response (InnateDB)
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GO:0045744
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negative regulation of G-protein coupled receptor protein signaling pathway
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GO:0050873
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brown fat cell differentiation
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GO:0055119
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relaxation of cardiac muscle
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GO:0060087
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relaxation of vascular smooth muscle
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GO:0060452
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positive regulation of cardiac muscle contraction
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GO:0071877
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regulation of adrenergic receptor signaling pathway
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Cellular Component |
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PDB ID |
MGI:1098271
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
O08849
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PhosphoSite |
PhosphoSite-O08849
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19735
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UniGene |
Mm.28262
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RefSeq |
NP_033087
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MGI ID |
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MGI Symbol |
Rgs2
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OMIM |
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CCDS |
CCDS15347
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HPRD |
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IMGT |
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EMBL |
AF215668
AF432916
AK031603
AK077922
AK162276
BC023001
U67187
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GenPept |
AAB50617
AAF34625
AAH23001
AAL28114
BAC27471
BAC37065
BAE36830
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