Version 5.4
Mus musculus Protein: Tmem188
Summary
InnateDB Protein IDBP-537932.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem188
Protein Name transmembrane protein 188
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000120121
InnateDB Gene IDBG-178383 (Tmem188)
Protein Structure
UniProt Annotation
Function Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Filamentous pattern in the cytoplasm. {ECO:0000250}.
Disease Associations
Tissue Specificity Muscle specific with lower expression in other metabolic tissues. {ECO:0000269PubMed:22134922}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006629 lipid metabolic process
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0034504 protein localization to nucleus
GO:0035307 positive regulation of protein dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0071595 Nem1-Spo7 phosphatase complex
Protein Structure and Domains
PDB ID MGI:1921981
InterPro IPR019168 Nuclear envelope phosphatase-regulatory subunit 1
PFAM PF09771
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UJ81
PhosphoSite PhosphoSite-Q3UJ81
TrEMBL
UniProt Splice Variant
Entrez Gene 382030
UniGene Mm.415951
RefSeq
MGI ID
MGI Symbol Cnep1r1
OMIM
CCDS
HPRD
IMGT
EMBL AK017198 AK146578 BC018498 BC148291
GenPept AAI48292 BAB30631 BAE27274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca