InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Laptm5

Summary

InnateDB Protein

IDBP-537994.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Laptm5

Protein Name

lysosomal-associated protein transmembrane 5

Synonyms

E3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118415

InnateDB Gene

IDBG-192935 (Laptm5)

Protein Structure

UniProt Annotation

Function

May have a special functional role during embryogenesis and in adult hematopoietic cells. {ECO:0000269PubMed:8661146}.

Subcellular Localization

Lysosome membrane {ECO:0000269PubMed:8661146}; Multi-pass membrane protein {ECO:0000269PubMed:8661146}.

Disease Associations

Tissue Specificity

Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. {ECO:0000269PubMed:8661146}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006810

transport

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:108046

InterPro

IPR004687 Lysosomal-associated transmembrane protein 4/5
IPR018396 Lysosomal-associated transmembrane protein, 4A/5

PFAM

PF03821

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61168

PhosphoSite

PhosphoSite-Q61168

TrEMBL

Q544S4

UniProt Splice Variant

Entrez Gene

16792

UniGene

RefSeq

NP_034816

MGI ID

MGI Symbol

Laptm5

OMIM

CCDS

CCDS18712

HPRD

IMGT

EMBL

AF364050 AK031802 AK050633 AK089508 AK153877 AK155353 AK155744 AK163146 AK170438 AK171053 AK171057 AK171149 AK171172 AK171213 AK171236 AK171244 AK171250 AK171269 AK171270 AK171285 AK171481 AK171547 AK171562 AK171571 AK171575 AK172486 AK172707 AK172717 BC020993 BC055057 BC158032 U29539 U51239

GenPept

AAB08976 AAB48192 AAH20993 AAH55057 AAI58033 AAK50858 BAC27556 BAC34354 BAC40908 BAE32226 BAE33211 BAE33412 BAE37213 BAE41796 BAE42214 BAE42216 BAE42276 BAE42292 BAE42317 BAE42332 BAE42337 BAE42342 BAE42355 BAE42356 BAE42368 BAE42482 BAE42520 BAE42527 BAE42532 BAE42535 BAE43030 BAE43139 BAE43142