InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polr3g

Summary

InnateDB Protein

IDBP-538132.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polr3g

Protein Name

polymerase (RNA) III (DNA directed) polypeptide G

Synonyms

2310047G20Rik; AV275904; RPC32; RPC7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125054

InnateDB Gene

IDBG-170102 (Polr3g)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001056	RNA polymerase III activity

Biological Process

GO:0006384	transcription initiation from RNA polymerase III promoter
GO:0008283	cell proliferation
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response
GO:0045089	positive regulation of innate immune response
GO:0051607	defense response to virus

Cellular Component

GO:0000790	nuclear chromatin
GO:0005666	DNA-directed RNA polymerase III complex

Protein Structure and Domains

PDB ID

MGI:1914736

InterPro

IPR024661 DNA-directed RNA polymerase III, subunit Rpc31

PFAM

PF11705

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6NXY9

PhosphoSite

PhosphoSite-Q6NXY9

TrEMBL

UniProt Splice Variant

Entrez Gene

67486

UniGene

Mm.279781

RefSeq

MGI ID

MGI Symbol

Polr3g

OMIM

CCDS

HPRD

IMGT

EMBL

AK010126 BC030063 BC066818

GenPept

AAH30063 AAH66818 BAB26717