InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wt1

Summary

InnateDB Protein

IDBP-538160.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wt1

Protein Name

Wilms tumor 1 homolog

Synonyms

D630046I19Rik; Wt-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117891

InnateDB Gene

IDBG-194872 (Wt1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0001656	metanephros development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0006309	apoptotic DNA fragmentation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007281	germ cell development
GO:0007507	heart development
GO:0007530	sex determination
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0009888	tissue development
GO:0017148	negative regulation of translation
GO:0030308	negative regulation of cell growth
GO:0030325	adrenal gland development
GO:0032835	glomerulus development
GO:0032836	glomerular basement membrane development
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061032	visceral serous pericardium development
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus
GO:0072207	metanephric epithelium development
GO:0072284	metanephric S-shaped body morphogenesis
GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development