InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp259

Summary

InnateDB Protein

IDBP-538239.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp259

Protein Name

zinc finger protein 259

Synonyms

AI303781; Zfp259; Znf259;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117725

InnateDB Gene

IDBG-161390 (Zfp259)

Protein Structure

UniProt Annotation

Function

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269PubMed:15767679, ECO:0000269PubMed:16648254, ECO:0000269PubMed:22422766, ECO:0000269PubMed:8650580}.

Subcellular Localization

Nucleus. Cytoplasm. Nucleus, nucleolus. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus, gem. Nucleus, Cajal body. Cell projection, axon. Cell projection, growth cone. Note=Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle- dependent manner. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner (By similarity). Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons. {ECO:0000250}.

Disease Associations

Note=May contribute to the severity of spinal muscular atrophy by increasing spinal motor neurons degeneration. {ECO:0000269PubMed:16648254}.

Tissue Specificity

Expressed in brain. Expressed in the spinal cord motor neurons (at protein level). Expressed in spleen, liver, muscle, kidney and testis. Expressed in the frontal cortex, cornus ammonis, dentate gyrus of the hippocampus and in Purkinje cells of the cerebellum. {ECO:0000269PubMed:16465397, ECO:0000269PubMed:16648254, ECO:0000269PubMed:8650580}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030971	receptor tyrosine kinase binding
GO:0031369	translation initiation factor binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001833	inner cell mass cell proliferation
GO:0001834	trophectodermal cell proliferation
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010628	positive regulation of gene expression
GO:0021510	spinal cord development
GO:0030576	Cajal body organization
GO:0031641	regulation of myelination
GO:0033120	positive regulation of RNA splicing
GO:0042023	DNA endoreduplication
GO:0042307	positive regulation of protein import into nucleus
GO:0045927	positive regulation of growth
GO:0061564	axon development
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071931	positive regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:1902742	apoptotic process involved in development
GO:1990261	pre-mRNA catabolic process
GO:2000672	negative regulation of motor neuron apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0030424	axon
GO:0030426	growth cone
GO:0032797	SMN complex
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm
GO:0097504	Gemini of coiled bodies