Version 5.4
Mus musculus Protein: Eomes
Summary
InnateDB Protein IDBP-538330.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eomes
Protein Name eomesodermin homolog (Xenopus laevis)
Synonyms C77258; TBR-2; Tbr2;
Species Mus musculus
Ensembl Protein ENSMUSP00000118079
InnateDB Gene IDBG-204135 (Eomes)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 0
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0001714 endodermal cell fate specification
GO:0001824 blastocyst development
GO:0001829 trophectodermal cell differentiation
GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010002 cardioblast differentiation
GO:0010468 regulation of gene expression
GO:0019827 stem cell maintenance
GO:0021772 olfactory bulb development
GO:0021796 cerebral cortex regionalization
GO:0030154 cell differentiation
GO:0032609 interferon-gamma production
GO:0035914 skeletal muscle cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045664 regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050767 regulation of neurogenesis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1201683
InterPro IPR001699 Transcription factor, T-box
IPR008967 p53-like transcription factor, DNA-binding
PFAM PF00907
PRINTS PR00937
PIRSF
SMART SM00425
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F6VSW9
UniProt Splice Variant
Entrez Gene 13813
UniGene Mm.200692
RefSeq
MGI ID
MGI Symbol Eomes
OMIM
CCDS
HPRD
IMGT
EMBL AC173340
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca