Version 5.4
Homo sapiens Protein: MYOZ3
Summary
InnateDB Protein IDBP-53841.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYOZ3
Protein Name myozenin 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000297130
InnateDB Gene IDBG-53839 (MYOZ3)
Protein Structure
UniProt Annotation
Function Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Subcellular Localization Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Localized at the Z-line of skeletal muscle. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed specifically in skeletal muscle. Not detected in heart. {ECO:0000269PubMed:11842093}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0030018 Z disc
Protein Structure and Domains
PDB ID
InterPro IPR008438 Myozenin
PFAM PF05556
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDC0
PhosphoSite PhosphoSite-Q8TDC0
TrEMBL H0YC50
UniProt Splice Variant
Entrez Gene 91977
UniGene Hs.91626
RefSeq NP_588612
HUGO HGNC:18565
OMIM 610735
CCDS CCDS4309
HPRD 17624
IMGT
EMBL AC008453 AF480443 AJ277961 AJ300586 AJ300587 AK313873 BC069380 BC069553 BC074870 BC074871 CH471062
GenPept AAH69380 AAH69553 AAH74870 AAH74871 AAL79336 BAG36601 CAC81912 CAC83076 CAC83077 EAW61713 EAW61714

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca