InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Megf8

Summary

InnateDB Protein

IDBP-538458.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Megf8

Protein Name

multiple EGF-like-domains 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122192

InnateDB Gene

IDBG-157440 (Megf8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest expression in brain, testis and kidney. {ECO:0000269PubMed:18821597}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0003143	embryonic heart tube morphogenesis
GO:0007275	multicellular organismal development
GO:0010468	regulation of gene expression
GO:0030326	embryonic limb morphogenesis
GO:0030509	BMP signaling pathway
GO:0035108	limb morphogenesis
GO:0042074	cell migration involved in gastrulation
GO:0048704	embryonic skeletal system morphogenesis
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0055113	epiboly involved in gastrulation with mouth forming second
GO:0060971	embryonic heart tube left/right pattern formation
GO:0060972	left/right pattern formation
GO:0061371	determination of heart left/right asymmetry
GO:0071907	determination of digestive tract left/right asymmetry
GO:0097094	craniofacial suture morphogenesis
GO:0097155	fasciculation of sensory neuron axon
GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2446294

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001881 EGF-like calcium-binding domain
IPR002049 EGF-like, laminin
IPR002165 Plexin
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR016201 Plexin-like fold

PFAM

PF00008
PF00431
PF07645
PF00053
PF01437

PRINTS

PIRSF

SMART

SM00181
SM00042
SM00179
SM00180
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P60882