InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sh3bp5

Summary

InnateDB Protein

IDBP-538464.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh3bp5

Protein Name

SH3-domain binding protein 5 (BTK-associated)

Synonyms

AI606498; Sab; SH3BP-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117152

InnateDB Gene

IDBG-146595 (Sh3bp5)

Protein Structure

UniProt Annotation

Function

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269PubMed:10339589}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1344391

InterPro

IPR007940 SH3-binding 5

PFAM

PF05276

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z131

PhosphoSite

PhosphoSite-Q9Z131

TrEMBL

UniProt Splice Variant

Entrez Gene

24056

UniGene

Mm.383198

RefSeq

MGI ID

MGI Symbol

Sh3bp5

OMIM

CCDS

HPRD

IMGT

EMBL

AB016835 AK043375 AK161427 BC018237 BC053741

GenPept

AAH18237 AAH53741 BAA75641 BAC31530 BAE36389