InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PELI1

Summary

InnateDB Protein

IDBP-53857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PELI1

Protein Name

pellino homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351789

InnateDB Gene

IDBG-53855 (PELI1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. {ECO:0000269PubMed:12496252, ECO:0000269PubMed:17675297}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0001819	positive regulation of cytokine production
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0008063	Toll signaling pathway
GO:0030890	positive regulation of B cell proliferation
GO:0031398	positive regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032496	response to lipopolysaccharide
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042130	negative regulation of T cell proliferation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043331	response to dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0050868	negative regulation of T cell activation
GO:0050871	positive regulation of B cell activation
GO:0070936	protein K48-linked ubiquitination