Version 5.4
Mus musculus Protein: Srsf2
Summary
InnateDB Protein IDBP-538573.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srsf2
Protein Name serine/arginine-rich splicing factor 2
Synonyms D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10; Sfrs2;
Species Mus musculus
Ensembl Protein ENSMUSP00000120086
InnateDB Gene IDBG-214528 (Srsf2)
Protein Structure
UniProt Annotation
Function Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA (By similarity). Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in all the tissues examined; liver, kidney, spleen, heart, lung and brain. {ECO:0000269PubMed:7527040}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 20 [view]
Protein-DNA 17 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:98284
InterPro IPR000504 RNA recognition motif domain
IPR003954 RNA recognition motif domain, eukaryote
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
SM00361
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62093
PhosphoSite PhosphoSite-Q62093
TrEMBL Q99MY5
UniProt Splice Variant
Entrez Gene 20382
UniGene Mm.469331
RefSeq XP_006532704
MGI ID
MGI Symbol Srsf2
OMIM
CCDS CCDS25680
HPRD
IMGT
EMBL AF077858 AF250132 AF250135 AK086103 AK088042 AK165670 BC005493 U14648 X98511
GenPept AAA64595 AAC71000 AAH05493 AAK28416 AAK28417 BAC39610 BAC40111 BAE38330 CAA67134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca