Mus musculus Protein: Ubc | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-538607.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ubc | ||||||||||||||||||||||
Protein Name | ubiquitin C | ||||||||||||||||||||||
Synonyms | 2700054O04Rik; AI194771; Rps27a; TI-225; Uba52; Ubb; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000114180 | ||||||||||||||||||||||
InnateDB Gene | IDBG-201307 (Ubc) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269PubMed:19754430}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 362 experimentally validated interaction(s) in this database.
They are also associated with 8383 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:98889 | ||||||||||||||||||||||
InterPro |
IPR000626
Ubiquitin-like IPR019956 Ubiquitin IPR022617 Rad60/SUMO-like domain IPR029071 Ubiquitin-related domain |
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PFAM |
PF00240
PF14560 PF11976 |
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PRINTS |
PR00348
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PIRSF | |||||||||||||||||||||||
SMART |
SM00213
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P0CG50 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P0CG50 | ||||||||||||||||||||||
TrEMBL | Q922Z8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 22190 | ||||||||||||||||||||||
UniGene | Mm.480760 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
MGI ID | 3VHT | ||||||||||||||||||||||
MGI Symbol | Ubc | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19684 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC138613 AF285161 AF285162 AK010964 AK168448 AL596181 BC006680 BC008661 BC021837 BC025894 BC036303 BC094012 D50527 EF580991 | ||||||||||||||||||||||
GenPept | AAG00512 AAG00513 AAH06680 AAH08661 AAH21837 AAH25894 AAH36303 AAH94012 ABQ52426 BAA09096 BAB27296 BAE40351 | ||||||||||||||||||||||