InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adra1a

Summary

InnateDB Protein

IDBP-538611.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adra1a

Protein Name

adrenergic receptor, alpha 1a

Synonyms

Adra1c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124322

InnateDB Gene

IDBG-175481 (Adra1a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity

Biological Process

GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007512	adult heart development
GO:0016049	cell growth
GO:0019229	regulation of vasoconstriction
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035265	organ growth
GO:0043410	positive regulation of MAPK cascade
GO:0055117	regulation of cardiac muscle contraction
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:104773

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001004 Alpha 1A adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)

PFAM

PF00001
PF10320
PF10323

PRINTS

PR00237
PR00557
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite