Version 5.4
Mus musculus Protein: Asb2
Summary
InnateDB Protein IDBP-538681.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asb2
Protein Name ankyrin repeat and SOCS box-containing 2
Synonyms 1110008E15Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000117595
InnateDB Gene IDBG-166569 (Asb2)
Protein Structure
UniProt Annotation
Function Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Highest expression in muscle, heart and spleen. {ECO:0000269PubMed:11111040}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0035556 intracellular signal transduction
GO:0035914 skeletal muscle cell differentiation
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045445 myoblast differentiation
Cellular Component
GO:0031466 Cul5-RING ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1929743
InterPro IPR001496 SOCS protein, C-terminal
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF07525
PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00253
SM00969
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K0L0
PhosphoSite PhosphoSite-Q8K0L0
TrEMBL
UniProt Splice Variant
Entrez Gene 65256
UniGene Mm.27159
RefSeq XP_006516200
MGI ID
MGI Symbol Asb2
OMIM
CCDS
HPRD
IMGT
EMBL AF155353 AK003566 BC031161
GenPept AAD38809 AAH31161 BAB22862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca