Version 5.4
Mus musculus Protein: Slain2
Summary
InnateDB Protein IDBP-538747.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slain2
Protein Name SLAIN motif family, member 2
Synonyms 5033405K12Rik; 8030444K12Rik; AI596370;
Species Mus musculus
Ensembl Protein ENSMUSP00000115871
InnateDB Gene IDBG-170346 (Slain2)
Protein Structure
UniProt Annotation
Function Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269PubMed:21646404}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007020 microtubule nucleation
GO:0031113 regulation of microtubule polymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0015630 microtubule cytoskeleton
GO:0035371 microtubule plus-end
Protein Structure and Domains
PDB ID MGI:1923241
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CI08
PhosphoSite PhosphoSite-Q8CI08
TrEMBL
UniProt Splice Variant
Entrez Gene 75991
UniGene Mm.121285
RefSeq NP_705795
MGI ID
MGI Symbol Slain2
OMIM
CCDS CCDS19335
HPRD
IMGT
EMBL AK129365 AK146432 BC010836 BC038019
GenPept AAH10836 AAH38019 BAC98175 BAE27166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca