InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klhl3

Summary

InnateDB Protein

IDBP-538837.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klhl3

Protein Name

kelch-like 3 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123701

InnateDB Gene

IDBG-157781 (Klhl3)

Protein Structure

UniProt Annotation

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

In kidney, predominantly localizes to the distal convoluted tubule (DCT) and collecting duct, with apical localization in the DCT (at protein level). {ECO:0000269PubMed:22266938, ECO:0000269PubMed:22406640}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003779	actin binding
GO:0003824	catalytic activity
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050801	ion homeostasis
GO:0070294	renal sodium ion absorption
GO:0070936	protein K48-linked ubiquitination
GO:0072156	distal tubule morphogenesis

Cellular Component

GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0031463	Cul3-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:2445185

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-E0CZ16

TrEMBL

J3KMI2

UniProt Splice Variant

Entrez Gene

100503085

UniGene

RefSeq

XP_006517071

MGI ID

MGI Symbol

Klhl3

OMIM

CCDS

HPRD

IMGT

EMBL

AC142258 AC165251

GenPept