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InnateDB Protein
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IDBP-538970.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atat1
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Protein Name
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alpha tubulin acetyltransferase 1
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Synonyms
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0610011P08Rik; 2610008K08Rik; 2610110G12Rik; 3110080J08Rik; Mec17; TAT;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000122715
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InnateDB Gene
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IDBG-179452 (Atat1)
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Protein Structure
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| Function |
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha- tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity (PubMed:23275437). {ECO:0000269PubMed:20829795, ECO:0000269PubMed:23275437, ECO:0000269PubMed:23720746, ECO:0000269PubMed:23748901, ECO:0000269PubMed:24097348}.
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| Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:23275437}. Cytoplasm, cytoskeleton {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:23275437}. Cell projection, axon {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:23275437}. Cytoplasm, cytoskeleton, spindle {ECO:0000255HAMAP-Rule:MF_03130, ECO:0000269PubMed:23275437}. Membrane, clathrin-coated pit {ECO:0000255HAMAP-Rule:MF_03130}. Cell junction, focal adhesion {ECO:0000255HAMAP-Rule:MF_03130}. Note=In primary root dorsal ganglion neurons, localizes with acetylated tubulin in axons. Recruited to the mitotic spindle during cell division.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed with highest levels in neuronal tissues. In the brain, expressed in the cortex, cerebellum and hippocampus, including the pyramidal layers in CA1 and CA3, as well as the granular cell layers in the lateral blade (suprapyramidal portion) and the medial blade (infrapyramidal portion) of the dentate gyrus. In testis, mainly expressed in the internal cell layers of seminiferous tubules, where spermatocytes and spermatids are located. {ECO:0000269PubMed:23275437, ECO:0000269PubMed:23720746}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
2
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
3 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0019799
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tubulin N-acetyltransferase activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1913869
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| InterPro |
IPR007965
Alpha-tubulin N-acetyltransferase
IPR016181
Acyl-CoA N-acyltransferase
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| PFAM |
PF05301
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q8K341
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| PhosphoSite |
PhosphoSite-Q8K341
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| TrEMBL |
B8JJ72
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| UniProt Splice Variant |
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| Entrez Gene |
73242
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| UniGene |
Mm.273155
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| RefSeq |
XP_006525053
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| MGI ID |
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| MGI Symbol |
Atat1
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AK028297
AK034725
AK133694
BC028847
BC030669
CR974451
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| GenPept |
AAH28847
AAH30669
BAC25866
BAC28808
BAE21786
CAX15764
CAX15766
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Version 5.4