Version 5.4
Mus musculus Protein: Th
Summary
InnateDB Protein IDBP-539053.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Th
Protein Name tyrosine hydroxylase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000122876
InnateDB Gene IDBG-212648 (Th)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004511 tyrosine 3-monooxygenase activity
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016597 amino acid binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0019825 oxygen binding
GO:0019904 protein domain specific binding
GO:0034617 tetrahydrobiopterin binding
GO:0035240 dopamine binding
Biological Process
GO:0001666 response to hypoxia
GO:0001963 synaptic transmission, dopaminergic
GO:0001975 response to amphetamine
GO:0006585 dopamine biosynthetic process from tyrosine
GO:0006631 fatty acid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0007507 heart development
GO:0007605 sensory perception of sound
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0009414 response to water deprivation
GO:0009416 response to light stimulus
GO:0009635 response to herbicide
GO:0009651 response to salt stress
GO:0009887 organ morphogenesis
GO:0010043 response to zinc ion
GO:0010259 multicellular organismal aging
GO:0014823 response to activity
GO:0015842 synaptic vesicle amine transport
GO:0016137 glycoside metabolic process
GO:0018963 phthalate metabolic process
GO:0021987 cerebral cortex development
GO:0031667 response to nutrient levels
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0033076 isoquinoline alkaloid metabolic process
GO:0035176 social behavior
GO:0035690 cellular response to drug
GO:0042214 terpene metabolic process
GO:0042418 epinephrine biosynthetic process
GO:0042421 norepinephrine biosynthetic process
GO:0042745 circadian sleep/wake cycle
GO:0042755 eating behavior
GO:0043434 response to peptide hormone
GO:0045471 response to ethanol
GO:0045472 response to ether
GO:0046684 response to pyrethroid
GO:0051412 response to corticosterone
GO:0051602 response to electrical stimulus
GO:0052314 phytoalexin metabolic process
GO:0055114 oxidation-reduction process
GO:0071287 cellular response to manganese ion
GO:0071316 cellular response to nicotine
GO:0071333 cellular response to glucose stimulus
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0008021 synaptic vesicle
GO:0009898 cytoplasmic side of plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0033162 melanosome membrane
GO:0043005 neuron projection
GO:0043195 terminal bouton
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID MGI:98735
InterPro IPR019774 Aromatic amino acid hydroxylase, C-terminal
IPR021164 Tyrosine hydroxylase, conserved site
PFAM PF00351
PF12549
PRINTS PR00372
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q91ZN2
UniProt Splice Variant
Entrez Gene 21823
UniGene Mm.1292
RefSeq
MGI ID
MGI Symbol Th
OMIM
CCDS
HPRD
IMGT
EMBL AC012382 AF415235
GenPept AAL09025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca