Version 5.4
Mus musculus Protein: Pigk
Summary
InnateDB Protein IDBP-539137.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pigk
Protein Name phosphatidylinositol glycan anchor biosynthesis, class K
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000123772
InnateDB Gene IDBG-200396 (Pigk)
Protein Structure
UniProt Annotation
Function Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0042765 GPI-anchor transamidase complex
Protein Structure and Domains
PDB ID MGI:1913863
InterPro IPR001096 Peptidase C13, legumain
PFAM PF01650
PRINTS PR00776
PIRSF PIRSF019663
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CXY9
PhosphoSite PhosphoSite-
TrEMBL Q80V43
UniProt Splice Variant
Entrez Gene 329777
UniGene Mm.404562
RefSeq NP_079938
MGI ID
MGI Symbol Pigk
OMIM
CCDS CCDS17919
HPRD
IMGT
EMBL AK013853 AK077893 AK082806 BC047203 BC060175 CH466532
GenPept AAH47203 AAH60175 BAB29018 BAC37051 BAC38629 EDL11916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca