InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmbim6

Summary

InnateDB Protein

IDBP-539213.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmbim6

Protein Name

transmembrane BAX inhibitor motif containing 6

Synonyms

5031406P05Rik; Bi1; Tegt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125117

InnateDB Gene

IDBG-183153 (Tmbim6)

Protein Structure

UniProt Annotation

Function

Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly abundant in adult testis. {ECO:0000269PubMed:8012111}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006986	response to unfolded protein
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress