InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo7b

Summary

InnateDB Protein

IDBP-539222.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo7b

Protein Name

myosin VIIB

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118046

InnateDB Gene

IDBG-133226 (Myo7b)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia. {ECO:0000269PubMed:11401444}.

Subcellular Localization

Apical cell membrane {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed primarily in kidney and intestine. Detected in proximal tubule cells of the kidney and enterocytes of the intestine, specifically the distal tips of apical microvilli on these transporting epithelial cells (at protein level). {ECO:0000269PubMed:11401444}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0008152

metabolic process

Cellular Component

GO:0005856	cytoskeleton
GO:0016324	apical plasma membrane
GO:0016459	myosin complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:107709

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000299 FERM domain
IPR000857 MyTH4 domain
IPR001452 SH3 domain
IPR001609 Myosin head, motor domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM

PF00612
PF00784
PF00018
PF14604
PF00063
PF00373

PRINTS

PR00452
PR00193

PIRSF

SMART

SM00015
SM00139
SM00326
SM00242
SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt