InnateDB Protein
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IDBP-539297.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fbxl3
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Protein Name
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F-box and leucine-rich repeat protein 3
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Synonyms
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AU041772; AW212966; FBK; Fbl3a; Fbxl3a; Ovtm; Play68;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000115843
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InnateDB Gene
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IDBG-184717 (Fbxl3)
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Protein Structure
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Function |
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. {ECO:0000269PubMed:17462724, ECO:0000269PubMed:17463252, ECO:0000269PubMed:18953409, ECO:0000269PubMed:23452855, ECO:0000269PubMed:23452856, ECO:0000269PubMed:23616524}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Predominantly nuclear.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed but enriched in brain. Diffusely expressed in the suprachiasmatic nucleus, SCN. {ECO:0000269PubMed:17462724, ECO:0000269PubMed:18953409}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
GO:0016567
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protein ubiquitination
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GO:0031146
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SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0031648
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protein destabilization
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GO:0042752
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regulation of circadian rhythm
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GO:0043153
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entrainment of circadian clock by photoperiod
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0048511
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rhythmic process
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Cellular Component |
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PDB ID |
MGI:1354702
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InterPro |
IPR001810
F-box domain
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PFAM |
PF00646
PF12937
PF13013
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PRINTS |
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PIRSF |
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SMART |
SM00256
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C4V4
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PhosphoSite |
PhosphoSite-Q8C4V4
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TrEMBL |
Q8BNS3
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UniProt Splice Variant |
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Entrez Gene |
50789
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UniGene |
Mm.214746
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RefSeq |
XP_006519303
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MGI ID |
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MGI Symbol |
Fbxl3
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC102815
AE013600
AF176521
AK080802
AK080863
BC046330
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GenPept |
AAF09131
AAH46330
AAM92567
BAC38026
BAC38050
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