Version 5.4
Homo sapiens Protein: EMC4
Summary
InnateDB Protein IDBP-5394.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EMC4
Protein Name transmembrane protein 85
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000249209
InnateDB Gene IDBG-5390 (EMC4)
Protein Structure
UniProt Annotation
Function May mediate anti-apoptotic activity.
Subcellular Localization Membrane {ECO:0000269PubMed:22119785}; Multi-pass membrane protein {ECO:0000269PubMed:22119785}.
Disease Associations
Tissue Specificity Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart. {ECO:0000269PubMed:18586032}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
Cellular Component
GO:0016021 integral component of membrane
GO:0072546 ER membrane protein complex
Protein Structure and Domains
PDB ID
InterPro IPR009445 Protein of unknown function DUF1077, TMEM85
PFAM PF06417
PRINTS
PIRSF PIRSF017207
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5J8M3
PhosphoSite PhosphoSite-Q5J8M3
TrEMBL
UniProt Splice Variant
Entrez Gene 51234
UniGene Hs.250905
RefSeq NP_001273349
HUGO HGNC:28032
OMIM
CCDS CCDS66732
HPRD 14233
IMGT
EMBL AC079203 AF151018 AK075227 AK290524 AK296184 AY336092 BC002583 CH471125
GenPept AAF36104 AAH02583 AAR24622 BAC11486 BAF83213 BAG58916 EAW92292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca