InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dtx2

Summary

InnateDB Protein

IDBP-539428.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dtx2

Protein Name

deltex 2 homolog (Drosophila)

Synonyms

2610524D08Rik; AA408415; AU022494; Deltex2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115122

InnateDB Gene

IDBG-204220 (Dtx2)

Protein Structure

UniProt Annotation

Function

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.

Disease Associations

Note=Recurrent site of retroviral integration in murine B-cell lymphomas.

Tissue Specificity

Expressed in testis and the CNS. {ECO:0000269PubMed:11226752}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0007219	Notch signaling pathway
GO:0016567	protein ubiquitination

Cellular Component

GO:0005737	cytoplasm
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:1921448

InterPro

IPR004170 WWE domain
IPR018123 WWE domain, subgroup

PFAM

PF02825

PRINTS

PIRSF

SMART

SM00678

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R3P2

PhosphoSite

PhosphoSite-Q8R3P2

TrEMBL

UniProt Splice Variant

Entrez Gene

74198

UniGene

Mm.275574

RefSeq

MGI ID

1V87

MGI Symbol

Dtx2

OMIM

CCDS

HPRD

IMGT

EMBL

AB015423 AB015424 AK012137 AK044105 AK054443 BC024925

GenPept

AAH24925 BAB18940 BAB18941 BAB28055 BAC31780 BAC35781